You play self-found hardcore? That’s even more hardcore.
You’ve had much more experience with higher SR than me, so if I were to try it, I’d have to find what the harder Nemeses would be. For Acid, it would be making sure to have enough DPS to get through Kaisan & Aleksander’s shards. or getting through Reaper’s adds. I’m not sure whether the Blight Fiend’s DPS would be enough to get through them with the new patch.
I tend to be more worried about things like Physical resistance & avoiding shotguns of burst damage. I’d be more inclined to try optimizing for higher SR once the new patch 1.1.9 comes out with the new SR boss realms.