I don’t know if anyone has a good feel for end game mechanics as they stand now. We just got a new expansion, new levels, new gear, and new classes.
That said, you want to find synergies to make a strong character, and good defense can make farming a lot easier. Typically, from my experience, resists take care of most damage types, but physical damage is a lot more complicated.
There is very little physical resist in the game, but armor can absorb a chunk of damage from every strike. Normally, your armor might only account for a small chunk of that damage, but if you can get physical resists up, then armor, and damage absorption can play a big role in lowering damage.
Shaman has an exclusive skill that has 15% damage absorption, and Savagery has 8% physical resists with 2h weapons. That, along with armor, and armor absorption can shore up your defense a fair bit along with some devotion points towards physical resists. Savagery also has offense and defense (to prevent crits).
Inquisitor has a good damage exclusive, along with 15% physical resist, and Inquisitor Seal for good damage boosts, and some flat damage reduction (not good for the big hits, but great for the steady stream of low hits).
Inquisitor comes with a big raw HP boost, while Shaman has an HP% boost buff.
I don’t know if there are any specific template builds for Inquisitor/Shaman, but they have good synergy with defense and 2h range. Your damage type may not synergize as well, but there should be enough to work with to make a build work well.
I want to experiment with one.