First, what is your aim here? Your choosen class combo is not usually for a standart melee or ranged attack build. People use it for Pet builds or casters, which neither of are in my understanding.
But as I said, you need to higher your resistances, in act 2 creatures mostly hit pierce, bleeding and physical but there are other types aswell. You have only decent elemental resistance, try to increase them as long as you can. The rest, you first say your aim then people/me can guide you to the right directions in skill line.
Anyway you seem to like Bone Harvest skill, it’s an unusual style for first build but examine this topic what it will be like to focus on that skill;