Also I am not sure about making changes per play through - as your reputation won’t change. E.g betraying her on ultimate, also makes her hostile on the lower difficulties.
If you didn’t do her quests in Normal and Elite but made her hostile in Ultimate, i’m pretty sure you can go back to Normal and Elite and change her to be friendly again.
You basically have three opportunities with her and by extension Death’s Vigil and Kymon’s Chosen.