Questions on Game Mechanics

Can anyone help me understand some game mechanics. I’m coming off a different game where attacking and casting are very different.

First, do “on Attack” skills apply when using a spell. For instance, would the Fireball from Francis’ Gun trigger when using Panetti’s Replicating Missile?

Second, can someone tell me why so many AAR builds are using Iskandra’s Elemental Exchange. It appears that the buffs only apply to weapon attacks, except for the increased energy regeneration.

Thank you,

  1. Yes
  2. Energy regen and crit damage from elemental balance

Thank you.