For the sake of illustration, Ravager of minds killed without pharma with the setup I’ve linked above (Conjurer, Level 100 (GD 1.1.9.3) - Grim Dawn Build Calculator - biggest difference from guide is on devo route) :
and Mogdrogen with just lighting resist pot and one Aether cluster:
I haven’t tried again with my current setup: Conjurer, Level 100 (GD 1.1.9.4) - Grim Dawn Build Calculator
edit: so I gave it a try… and died.
I’ve then equipped back my Solael-Sect Pants and an Impassable Vampiric Bonewall of Decay for 17% more physical resistance, and I’ve killed it again without any sweat. Still lots of hit miss though as I lose a good bunch of OA with this switch.