Yeah. For a while, for deep SR, I was looking very seriously into making Reduction to Enemy Health dps builds with Bloody Pox and dual-wielding Myth. Demonslayer’s Life Enders, or Deathdealer’s for Exterminate.
This was one of the first forays into exploring the potential damage of health reduction in deep sr : 72m Damage Using Bloody Pox (lol) - #3 by WyreZ
What I found was that it IS great for clearing *some * trash, but… it has 0 effect on bosses. On Grimtools the nemesis’ have listed ~96% resistance to life reduction, but when Grim Internals was running, I could see that it was dealing 0 life reduction damage to most bosses… so the incredible benefits of significantly reducing down chunks of enemy hp at the start of fights became significantly thwarted by them otherwise doing suboptimal damage during the important fights…