There are many players who dont really follow the meta though. Im one of those players, and theres so much more to this debate in my opinion than how effective the rune is at making it easier to kill stuff. It is the manner by which my combat is experienced that makes disengage more appealing 90% of the time. My favorites are the ones that either freeze or petrify, because i love immobilization skills and effects. It makes the distance put between you and the enemy even more relevant as theyre immobilized, which buys you additional time.
Something i love about GD is the combat pace. Its slower than PoE and Diablo 3. You have time to think and can approach fights tactfully, if desired. It should be noted im not talking about Curcible, or SR, just MC. I love the MC of this game, and nowhere is this pace of combat felt more than in MC.
I think to really express my perspective i need to provide some examples of what i enjoy about playing the game more tactically and at a slower pace (one place where disengage runes feel like a “win more” by your definition) so here is one example;
Every now and then, for fun, i like to play on the plains of strife and see how many enemies i can lure into the mines scattered across the battlefield, and furthermore, into the small black legion detachments scattered in the area. Particularly on a difficulty level where my character is far outmatched by the enemies which are present, or using a character that buffs and heals allies. I like to see how many of the enemies i can eliminate primarily using the mines on the field and the black legion NPCs. Its also interesting to see if i can heal the NPCs to keep them from dying while they fight these enemies. I take my time with it. Every mine an enemy detonates is one less mine i have to worry about stepping on, and i work my way around seeing if I can clear a path. The challenge of this playstyle is awesome.
I will go so far as to choose builds with intentional disadvantages built into them, with the goals being to experience the game in this weird kind of way, with areas of the game like this in mind- these are self imposed rules, much like playing HC classless. On many of these builds, disengage just feels thematically more fitting, while simultaneously allowing for a wildly different gameplay approach, and can also reinforce the feel of a character. I have a Stun jacks purifier (Gambit), who uses disengage because thats a Gambity thing to do. I dont picture Gambit leaping into the fray, or dashing across the ground. I certainly dont see Gambit teleporting. Disengage fits him perfectly. I also run a 2H acid Dervish (Oberyn Martell) who uses disengage, but also uses vires might, because both suit this theme.
I do not personally care about a better way to kill things, as you can see. My goal is not to be fast or efficient. Its to explore other ways that are possible to experience this great game- possible because of things like disengage runes, which do something unique. This is more fun to me, and so for my own purposes, on the weird builds i love to play with, disengage runes are often the most appealing.
Im definitely a noob and ill never deny or argue about that, theres a lot i dont know about this game. But im not new, ive put over 2000 hours into it, BECAUSE of things like disengage runes and healer skills. I guess this is the main reason i dont follow the “meta”, and why its difficult for me to see the term “lose less” applying to disengage runes, unless we are specifically talking about endgaming farming meta. Maybe then i guess?
The OP didnt specify thats what he was asking about though, so its important all perspectives are given.
EDIT: I forgot to mention the Blade Trap build that uses a disengage rune. This is my Itachi Uchiha build. An infiltrator, also uses Shadow Strike because both fit the theme. Let me tell you, disengage really just feels awesome on this guy.