for endgame, no
during levelling you can potentially out level enemies on Normal and Elite because of area level max scaling, but that’s it
if you’re more than 10 levels above enemies they wont give kill reputation
if you’re more than 12 level above enemies they wont drop purple crafting material
this can only potentially happen on Normal and Elite if you overstay/out level a specific zone, never on Ultimate tho where enemies will always scale to max level
enemies will still drop regular items, and blueprints even if you are higher level, only potential issue there will be loot is scaled by the monster level you kill, so if you’re on normal with a level 70 character in a lvl 50 area, you might not exactly get level relevant item drops
again this wont be an issue on Ultimate where areas and enemies constantly scale to max level
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