It really depends on your playstyle preference, because how each set/skill/mastery functions mechanically depends on the “archetype” you choose to follow.
My favorite has always been high DPS casters, which stay alive mostly through positioning.
So the builds you’ll tend to see me post involve predominantly a hit-'n-run playstyle.
i.e. I’ll appear in front of a priority target, destroy it in seconds, and vanish before I get surrounded. here’s my most recent post
Superfluff and Nery both love dual wield melee. This playstyle involves getting up-close and personal, and cutting swathes through enemy mobs.
This playstyle is unfortunately not as “efficient” as it used to be given the number of debuffs enemies can stack on you.
Then you have your classic sword-'n-board tank where you opt to outlast your enemies, as opposed to outkilling them.
The list goes on and on.
So what would be helpful is if you could first decide on an archetype YOU find cool. That’ll help narrow your search parameters, if that makes sense.