I wanted to get an achievement for killing Anasteria. Having received it, I pressed alt+F4, but when I re-entered, I had a negative reputation with her faction -1 (although according to the community it should be -3) and an NPC that is not aggressive towards me, you can even talk to her, but only the option to close the dialogue is available. The task is to kill her. But the mission is impossible. Perhaps, such NPCs should be tied to reputation and not to a script that CAN break 
Perhaps, game must be closed with standard means and not emergency shortcut that CAN break data.
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yes, altf4 = doesnt’ get to save latest progress
i’m guessing it’s because the game saves at “certain moments”, one of those moments is using the menu button to manually exit
AltF4 results in same progress loss/unsaved progress state as game crash or killing the game process from task manager etc from my experiments
Alt+F4 still gives programs a chance to save something, but they have to specifically handle such event.
Not sure what the hope to alt-f4 was? Were you trying to complete the quest both ways on one character?
If you attach your save, I can restore it to be correctly hostile with Anasteria.
I thank you for the suggestion for a fix, but here is my message so this doesn’t happen in the future. I used alt+f4 to get the steam achievement for killing anasteria (I hadn’t killed her before), and then came back and played as a friend. I forget to make backups of characters when not playing on hardcore.