When i´m starting over with a random new map from within a running game i´ll be stuck on the loading screen (i waited at least 10min) and the only thing to do is pressing ALT-F4.
Make sure that you have enough RAM memory available and that nothing else is significantly using your CPU, as the game can freeze or at least become very slow if that happens, making loading times much longer or even indefinite. This essentially applies to all programs, but this game can just spike its CPU usage quite heavily and consume quite a bit of RAM as well.
Yeah should be fine as long as not too much else is running, as I’ve seen the game using between 6 - 12 Gigs, depending on city size, map size and so on.