Nothing, really. T’was a joke referring to The Grim Creeper’s self-proclaimed “best builds”
This is my only rune build but I have another runebinder build that focuses on Runic Bolts (the skill given by the weapon) instead of runes. You might wanna check that out. It can also be any inquisitor class, so you have a lot of options. Check 2nd post of that thread for classes other than tactician.
http://www.grimdawn.com/forums/showthread.php?t=69745