I was stuck on Nightmare Andariel a number of days, with the recognition that my current build was meant more as a meme that actually began to work, than something truly serious. But I want to mention it because of the extreme changes I went through just to kill her.
Once I had my items PERFECT including 20% attack speed with runes on all possible items, crafted other items, and changed out and added/buffed yet other items including a Perfect Prism on my weapon, fully reprioritized my skills without doing a different build entirely (this took alot of work and many tries), and completely going offensive with the exception of one good passive section with retaliation and health, I was finally able to take her out pretty quickly but still with a struggle.
The ONE passive that actually helped was lifesteal, so I left that in. I then switched all passives back, kept my skills the same, and kept my items the same as I was selling other items just to get enough health potions fighting Andariel hours on end and continually dying, I am finally ready to continue my journey in act 2. I defeated Normal + Baal before I’d done the more massive changes.
The emphasis is that even with an EXTREMELY offensive build and 150% attack speed with around 60k max damage, I couldn’t take her out. Going to 170% attack speed with lifesteal took me over the top. Few of the defensive passives really helped at all even though many skills I tried only mildly increased my DPS (passive skills). While I know that poison damage is being nerfed on Andariel in the next patch, I still wanted to relay how difficult this was.
I took this route instead of the long boring way of leveling to over 70 with a world boss (by killing his minions and him sometimes), because I figured at level 61 I was well ahead of the curve and SHOULD be able to do SOMETHING to defeat her. I don’t think poison damage itself was the main problem, and was instead Andariel’s massively fast healing that was the culprit, requiring enormous amounts of DPS and completely abandoning my built to an extreme level just so I could progress.
While my build wasn’t great, it wasn’t terrible, and even optimal items was not enough to take her out. On my items I also had to abandon shield block, we’re talking at least 25% worth. I’m leaving that AS IS since I’m totally broke, LOL.
I had to relocate 20 passives out of the 33 or so I’ve received so far.
I could further test it to see if more defense would have worked with 170% attack speed on the passive end, but I’m out of gold.
EDIT: While I didn’t have alot of dex, Andariel was 85% chance to hit her, so that wasn’t really a problem at all.
EDIT 2: An hour or two after typing this I remembered Prevent Monster Heal. I don’t think I had this statistic anywhere.