For those who don’t know the M4ssboss3s mod, here’s Quique’s excellent summary which also gives the boss numbers you’ll face when playing the game.
"M4ssboss3s Guide - Quique
General criteria: first of all, you have to find the previous monster multipliers easy when playing with your toon. (Typhoon Mod is quite useful to test this: if you find it quite easy, then your toon has good chances to succeed when playing M4ssboss3s…at least when fighting against common monsters).
And then, when fighting bosses a few criteria (You don´t need all of them, but at least two (3 would be the advisable quiantity).
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High damage attack. What I mean here is to count on at attack that allows your toon to kill a boss with 2 or 3 hits (a “harrower” or a “smiter”).
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a great AOE atttack always available (any of them: Markmanship, Ice Shards, and Ternion Attack; and all the possibilities that are given by a -100 recharge gear).
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Strong on defense: there are a lot of possibilities here: damage absorbtion; high resistances (the resistances under M4ssboss3s doesn´t guarantee that your toon will stay alive, but low resistances usually means instant death here); 100% ctap+high DA, ADCTH, etc…
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A ranged attack. I include this on the defensive part just because the is the most useful tactic on this mod, so use and abuse the static attack key. Is something (What I mean here is to attack in complete immunity…that key is quite important even in vanilla game, but while in vanilla game or even in softer multipliers I don´t like to use that to take advantage of inflicting damage in a total inmunity situation, sometimes in M4ssboss3s Mod you don´t have other choice) that I don´t like to use under other moster multipliers, but is the only thing that you can do in a lot of situations when playing at M4ssboss3s mod.
I include below the number of each boss in this mod (apply to each number a small margin of error):
Act I: Nessus (24), Polyphemus (24), Aracne (24), Gorgon sisters (24x3), Hidra (9), Alastor (24), Talos (9), Minotaur Lord (24), Megalesios (18).
Act II: Scarab (24), Statues under the sphinx (4 of each; and good news here: the numer of statues and canopies are the same, so once you have killed all the statues you can enter the room to take the “hand of eternity”), Nehebkau (24), Manticore (9), Aktaios (18), Sand Spectre (24).
Act III: Chimera (24), Barmanu (24), Yeti (24), Xiao, the giant peng (24), Bandari (24), Liche Dragon (9), Yaoguai (24), Ormenos (12).
Olympus: Typhon (24).
Act IV: Gray Sisters (12x3), Charon (12), Cerberus (12), Undead Typhon (12), and Hades (12)."
You’ll also face 24 Satyr mages as part of the Helos quest. You will not face 24 Anteok bosses as part of the Outpost in the Woods side quest - they will simply not appear. To do that quest you’ll need to drop out of the mod into normal game to fight him and then go back into the mod at the next rebirth fountain. Or you can just go to the cave and loot it, but you won’t be able to complete the quest obviously.
The mod has a lot of heroes who appear in groups of 5/6 of each. This was my experience when, in my folly, I decided to run the mod with a brand new L1 toon to make a journal of my Diviner’s progress through the mod.
“First big surprise - like the Achilles mod this one also has heroes spawning all over the place. I ran into Caldor Darkbow, Marnos Rockbiter and Algos Frostwind in multiple forms just past the Helos bridge and died twice trying to deal with them all because I wasn’t expecting them.”
You also have a good chance of running into Toxeus the Green x5/6 anywhere that undead hang out. If you thought Toxeus in the Secret Passage was hard, he’s a doddle compared to the Green version. Stock up on damage to undead/less damage from undead items - and pray you survive.
The mod can lag BIG TIME - when I tried to do the Scarab bosses down in the Rhakotis Library I simply couldn’t do it. The lag was so bad on my PC that I ended up having to shift back to the normal game to complete that part before switching back to the mod again.
As said previously, this mod is more for farming purposes with an already high level toon rather than a mod you start with a brand new toon. It can be done, but boy can it be painful doing so.