All of the above then. Uhh, for all super-bosses you probably want a specialized build. Even mogdrogen I don’t think you could do without pharma + some other source of lightning res (armor augments maybe?) I see little reason you couldn’t do buffed crucible or push SR with enough persistence (both need practice in addition to building).
Your spec is quite similar to two well established builds: John_Smith’s Shieldbreaker, and Sir Spanksalot’s Purifier. You could draw on these for inspiration. As Sir Spanksalot discusses in his purifier build, you can’t get enough points into inquisitor seal and will be moving too often to use it. Personally, I think shieldbreaker is better for a single bomb build just for mobility; Ascension > Seal.