Lost Souls got some pretty good buffs with 18.104.22.168, and went from barely playable to quite potent. The set has support for both Skeletons and Hellhounds, but the best usage I’ve found is to use Skeletons and Wraiths. If you’re looking for a powerful, easy to play Skeleton build, this is the build for you.
There are a ton of variants of this that work fine. They all perform so similarly that it’s hard to determine which performs “best”.
Dying God + Ishtak (main setup)
This setup uses Fiendgaze Tome to convert the Wraith’s Cold and some of the Skeletons Physical damage to Chaos. Voidwhisper Bands on paper look like they’d be great with Lost Souls but it is much more important to get Reap Spirit to 23/16 to get a third Wraith, and while it is possible to do so without Spiritbinder Glyphs, the cost is not worth the benefit.
This setup ends up with a bit more DA and health than the Vitality setup, and does a little better against Kubacabra, but does worse against Reaper who is heavily resistant to Chaos. I think this is slightly more powerful overall, but the difference is within the margin of error.
Vitality damage on pets is in a weird place. Vitality is one of the most resisted damage types in the game, and requries a ton of RR. All pet classes have their own Vitality RR, but there almost no pet items with additional RR, and the constellation with that provides Vitality RR is so far out of the way for pet builds that you’re worse off taking it than not. I’ve found that pet vitality builds the most inconsistent in both Crucible and SR of any builds I’ve played, depending on spawns and modifiers. At it’s best Lost Souls can get as low as 6:00 in Crucible and do SR 80+, but the same setups sometimes have 7:30 Gladiators runs and fail hard at SR 75.
Unfortunately, Hellhounds on Lost Souls are very lackluster. Hellhound require a ton of skill point investment to make them useful and even then they are not sufficiently strong on their own to carry a build, particularly when forced into Vitality damage which is notoriously difficulty to work with for pets. Skeletons require a ton of skill point investment in both the Raise Skeleton skill tree and in support skills. There just aren’t enough points to invest in both, and the Skeletons are a lot more effective. Wraiths provide much more firepower for a modest investment, and are a better choice overall.
Another significant hurdle faced when trying to use both Hellhounds and Skeletons together is that the Hellhounds are not very good at path finding. They spend a lot of time running around in circles trying to reach targets instead of attacking.
I’ve tried doing Hellhound + Wraith Lost Souls ultimately failed repeatedly.